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19th Annual Koch Institute Summer Symposium on Cancer Immunotherapy, June 12, 2020 at MIT’s Kresge Auditorium Reporter: Aviva Lev-Ari, PhD, RN     Summer Symposium 2020 Engineering the Next Wave of Immunotherapy The 19th Annual Koch Institute Summer Symposium on June 12, 2020 at MIT’s Kresge Auditorium will focus on cancer immunotherapy. Cancer immunotherapy has revolutionized the […]

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New Mutant KRAS Inhibitors Are Showing Promise in Cancer Clinical Trials: Hope For the Once ‘Undruggable’ Target Curator: Stephen J. Williams, Ph.D. The November 1st issue of Science highlights a series of findings which give cancer researchers some hope in finally winning a thirty year war with the discovery of drugs that target KRAS, one […]

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Deep Learning extracts Histopathological Patterns and accurately discriminates 28 Cancer and 14 Normal Tissue Types: Pan-cancer Computational Histopathology Analysis Reporter: Aviva Lev-Ari, PhD, RN Pan-cancer computational histopathology reveals mutations, tumor composition and prognosis Yu Fu1, Alexander W Jung1, Ramon Viñas Torne1, Santiago Gonzalez1,2, Harald Vöhringer1, Mercedes Jimenez-Linan3, Luiza Moore3,4, and Moritz Gerstung#1,5 # to whom […]

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Cancer Genomics: Multiomic Analysis of Single Cells and Tumor Heterogeneity Curator: Stephen J. Williams, PhD   scTrio-seq identifies colon cancer lineages Single-cell multiomics sequencing and analyses of human colorectal cancer. Shuhui Bian et al. Science  30 Nov 2018:Vol. 362, Issue 6418, pp. 1060-1063 To better design treatments for cancer, it is important to understand the […]

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Complex rearrangements and oncogene amplification revealed by long-read DNA and RNA sequencing of a breast cancer cell line Reporter: Stephen J. Williams, PhD In a Genome Research report by Marie Nattestad et al. [1], the SK-BR-3 breast cancer cell line was sequenced using a long read single molecule sequencing protocol in order to develop one […]

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Using A.I. to Detect Lung Cancer gets an A! Reporter: Irina Robu, PhD Google researchers hypothesized that computers are as good or better than doctors at detecting tiny lung cancers on CT scans, since CT scan combines data from several X-rays to produce a detailed image of a structure inside the body. CT scans produce […]

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The Sylvester Comprehensive Cancer Center of the University of Miami named 71st NCI designated Cancer Center   Reporter: Stephen J. Williams, PhD As seen in the Cancer Letter at https://cancerletter.com/articles/20190729_1/ Conversation with The Cancer Letter Sylvester becomes 71st NCI-designated cancer center Stephen Nimer Director, Sylvester Comprehensive Cancer Center   After six years of  aggressively recruiting and spending […]

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An Intelligent DNA Nanorobot to Fight Cancer by Targeting HER2 Expression Reporter and Curator: Dr. Sudipta Saha, Ph.D.   HER2 is an important prognostic biomarker for 20–30% of breast cancers, which is the most common cancer in women. Overexpression of the HER2 receptor stimulates breast cells to proliferate and differentiate uncontrollably, thereby enhancing the malignancy of […]

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Single-cell RNA-seq helps in finding intra-tumoral heterogeneity in pancreatic cancer Reporter and Curator: Dr. Sudipta Saha, Ph.D.   Pancreatic cancer is a significant cause of cancer mortality; therefore, the development of early diagnostic strategies and effective treatment is essential. Improvements in imaging technology, as well as use of biomarkers are changing the way that pancreas […]

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Engineered Bacteria used as Trojan Horse for Cancer Immunotherapy Reporter: Irina Robu, PhD Researchers are using synthetic biology— design and construction of new biological entities such as enzymes, genetic circuits, and cells or the redesign of existing biological systems—is changing medicine leading to innovative solution in molecular-based therapeutics. To address the issue of designing therapies that can induce a […]

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