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CRISPR cuts turn gels into biological watchdogs Reporter: Irina Robu, PhD Genome editing if of significant interest in the prevention and treatment of human diseases including single-gene disorders such as cystic fibrosis, hemophilia and sickle cell disease. It also shows great promise for the prevention and treatment of diseases such as cancer, heart disease, mental […]

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Merck KGaA-owned Sigma-Aldrich has petitioned the US Patent and Trademark Office (USPTO) to open an interference proceeding between its own pending CRISPR-Cas9 patents and patents awarded to the University of California, Berkeley (UC Berkeley). On Friday, July 19, Sigma-Aldrich submitted the request, available on blog PatentDocs, asking for a parallel interference to the one declared by the […]

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At Technical University of Munich (TUM) Successful Genetical modification of a patient’s own immune cells, T cell receptors, using CRISPR-Cas9 gene editing tool. The engineered T cells are very similar to the physiological immune cells. Reporter: Aviva Lev-Ari, PhD, RN   Targeted exchange using the CRISPR-Cas9 gene scissors The problem with conventional methods is that the […]

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FIVE Forthcoming Books on CRISPR in 2019-2020: Flooded market or CRISPR-fatigued readers – Not to Worry !!!!! Author: Aviva Lev-Ari, PhD, RN   From: Aviva Lev-Ari <AvivaLev-Ari@alum.berkeley.edu> Date: Thursday, July 4, 2019 at 8:39 PM To: <damian.garde@statnews.com> Cc: Marcus W Feldman <mfeldman@stanford.edu>, “Stephen Williams, PhD” <sjwilliamspa@comcast.net>, Aviva Lev-Ari <AvivaLev-Ari@alum.berkeley.edu>, Gail Thornton <gailsthornton@yahoo.com> Subject: Regarding your […]

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Optimization of CRISPR Gene Editing with Gold Nanoparticles Reporter: Irina Robu, PhD The CRISPR-Cas9 gene editing system has been welcomed as a hopeful solution to a range of genetic diseases, but the expertise has proven hard to deliver into cells. One plan is to open the cell membrane using an electric shock, but that can […]

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Breakthrough in Gene Editing CRISPR–Cas systems: First example of a fully programmable, RNA-guided integrase and lays the foundation for genomic manipulations that obviate the requirements for double-strand breaks and homology-directed repair.   Reporter: Aviva Lev-Ari, PhD, RN   CRISPR alternatives for editing genes without cutting: CRISPR 12, 12a, 13, 14 – Alternative Techniques to CRISPR/Cas9 […]

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Laboratory for Genomics Research (LGR) to be established by GSK ($67M investment in 5 years) at UC, Berkeley/UCSF to be lead by Prof. Jennifer Doudna focusing on immunology, oncology, and neuroscience disease-causing gene mutations and development of new technologies using CRISPR to accelerate new drug discovery   Reporter: Aviva Lev-Ari, PhD, RN   GlaxoSmithKline, UC’s […]

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Alternative to CRISPR/Cas9 – CAST (CRISPR-associated transposase) – A New Gene-editing Approach for Insertion of Large DNA Sequences into a Genome developed @BroadInstitute @MIT @Harvard Reporter: Aviva Lev-Ari, PhD, RN   A new gene-editing CAST member In Science, a team led by Jonathan Strecker, Alim Ladha, and core institute member Feng Zhang reports a new gene-editing approach that […]

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Top 10 CRISPR Podcasts Every Scientist (& Non-Scientist) by Synthego.com Reporter: Aviva Lev-Ari, PhD, RN     On 3/12/2015 – Dr. Williams posted Podcast Review: Quiet Innovation Podcast on Obtaining $ for Your Startup Reporter: Stephen J. Williams, Ph.D. https://pharmaceuticalintelligence.com/2015/03/12/podcast-review-quiet-innovation-podcast-on-obtaining-for-your-startup/   On 1/25/2016 – I posted Launching LPBI’s, Fourth Line of Business (D): FIVE Podcast – Audio […]

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Opportunities and Ethics of Editing Genomes: A CRISPR-Inspired Conversation, Prof. Jennifer Doudna’s Lecture at Stanford University, JANUARY 24, 2019 – 7:00PM TO 8:30PM, CEMEX AUDITORIUM, GRADUATE SCHOOL OF BUSINESS Reporter: Aviva Lev-Ari, PhD, RN   Opportunities and Ethics of Editing Genomes: A CRISPR-Inspired Conversation JANUARY 24, 2019 – 7:00PM TO 8:30PM EVENT SERIES: ARROW LECTURES EVENT SPONSOR: CENTER […]

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