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The Promise of Low-Dose Aspirin on Longevity in the Geriatric Population: No Effect on Outcomes in the US and Australia

Posted in Atherogenic Processes & Pathology, Cardiovascular Research, Coagulation Therapy and Internal Bleeding, Frontiers in Cardiology and Cardiovascular Disorders, HTN, inflammation independent of lipid levels, Pharmacotherapy of Cardiovascular Disease, Stroke on September 24, 2018| Leave a Comment »


The Promise of Low-Dose Aspirin on Longevity in the Geriatric Population: No Effect on Outcomes in the US and Australia Reporter: Aviva Lev-Ari, PhD, RN UPDATED on 10/17/2018 https://www.nejm.org/doi/full/10.1056/NEJMoa1800722 Effect of Aspirin on Disability-free Survival in the Elderly ORIGINAL ARTICLE Effect of Aspirin on Disability-free Survival in the Healthy Elderly J.J. McNeil and Others      […]

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Aspirin Advocate vs Skeptic: Any Common Ground? – Medscape

Posted in Uncategorized on November 3, 2014| Leave a Comment »


UPDATED on 7/17/2016 Aspirin Fails to Prevent Cardiovascular Events in High-Risk Patients Significant bleeding risk may outweigh any benefit Aspirin Fails to Prevent Cardiovascular Events in High-Risk Patients   Aspirin Advocate vs Skeptic: Any Common Ground? Source: login.medscape.com See on Scoop.it – Cardiovascular Disease: PHARMACO-THERAPY

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Intracranial Vascular Stenosis: Comparison of Clinical Trials: Percutaneous Transluminal Angioplasty and Stenting (PTAS) vs. Clot-inhibiting Drugs: Aspirin and Clopidogrel (dual antiplatelet therapy) – more Strokes if Stenting

Posted in Atherogenic Processes & Pathology, Cardiac and Cardiovascular Surgical Procedures, Cerebrovascular and Neurodegenerative Diseases, Innovations in Neurophysiology & Neuropsychology, PCI on October 15, 2014| 2 Comments »


Intracranial Vascular Stenosis: Comparison of Clinical Trials: Percutaneous Transluminal Angioplasty and Stenting (PTAS) vs. Clot-inhibiting Drugs: Aspirin and Clopidogrel (dual antiplatelet therapy) – more Strokes if Stenting   Reporter: Aviva Lev-Ari, PhD, RN   UPDATED on 8/5/2018 Clopidogrel plus aspirin bests aspirin alone for CV event reduction: Cochrane Source: JAMA, Published online July 26, 2018. doi:10.1001/jama.2018.9641 Curated […]

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Platelet Endothelial Aggregation Receptor-1 (PEAR1) Gene to be most strongly associated with Dual Antiplatelet Therapy Response: Genetic Determinants of Variable Response to Aspirin (alone and in combination with Clopidogrel)

Posted in Atherogenic Processes & Pathology, Cardiac and Cardiovascular Surgical Procedures, Cardiovascular Pharmacogenomics, Cardiovascular Research, Cell Biology, Signaling & Cell Circuits, Chemical Genetics, Coagulation Therapy and Internal Bleeding, Computational Biology/Systems and Bioinformatics, FDA Regulatory Affairs, Frontiers in Cardiology and Cardiovascular Disorders, Genome Biology, Genomic Testing: Methodology for Diagnosis, HTN, Medical and Population Genetics, Origins of Cardiovascular Disease, PCI, Personalized and Precision Medicine & Genomic Research, Pharmacotherapy of Cardiovascular Disease, Stents & Tools, Valves & Tools, tagged , , , , , , on December 30, 2013| Leave a Comment »


Platelet Endothelial Aggregation Receptor-1 (PEAR1) Gene to be most strongly associated with Dual Antiplatelet Therapy Response: Genetic Determinants of Variable Response to Aspirin (alone and in combination with Clopidogrel) Reporter: Aviva Lev-Ari, PhD, RN 4 Genetic Variation in PEAR1 is Associated with Platelet Aggregation and Cardiovascular Outcomes Joshua P. Lewis1, Kathleen Ryan1, Jeffrey R. O’Connell1, Richard B. Horenstein1,Coleen M. Damcott1, Quince […]

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PIK3CA mutation in Colorectal Cancer may serve as a Predictive Molecular Biomarker for adjuvant Aspirin therapy

Posted in Biological Networks, Gene Regulation and Evolution, Biomarkers & Medical Diagnostics, CANCER BIOLOGY & Innovations in Cancer Therapy, Cell Biology, Signaling & Cell Circuits, Chemical Biology and its relations to Metabolic Disease, Chemical Genetics, Genome Biology, Genomic Testing: Methodology for Diagnosis, Liver & Digestive Diseases Research, Medical and Population Genetics, Metabolomics, Molecular Genetics & Pharmaceutical, Personalized and Precision Medicine & Genomic Research, Population Health Management, Genetics & Pharmaceutical, tagged , , , , , , on November 28, 2012| 8 Comments »


Reporter: Aviva Lev-Ari, PhD, RN Aspirin Use, Tumor PIK3CA Mutation, and Colorectal-Cancer Survival N Engl J Med 2012; 367:1596-1606 October 25, 2012DOI: 10.1056/NEJMoa1207756 BACKGROUND Regular use of aspirin after a diagnosis of colon cancer has been associated with a superior clinical outcome. Experimental evidence suggests that inhibition of prostaglandin-endoperoxide synthase 2 (PTGS2) (also known as cyclooxygenase-2) by aspirin […]

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Aspirin a Day Tied to Lower Cancer Mortality

Posted in CANCER BIOLOGY & Innovations in Cancer Therapy, Cell Biology, Signaling & Cell Circuits, Chemical Biology and its relations to Metabolic Disease, tagged , , , , , , on August 11, 2012| 4 Comments »


Aspirin a Day Tied to Lower Cancer Mortality Reporter: Aviva Lev-Ari, PhD, RN Aspirin a Day Tied to Lower Cancer Mortality Download Complimentary Source PDF  By Nancy Walsh, Staff Writer, MedPage Today Published: August 10, 2012 Reviewed by Zalman S. Agus, MD; Emeritus Professor, Perelman School of Medicine at the University of Pennsylvania  http://www.medpagetoday.com/HematologyOncology/OtherCancers/34149?utm_content=&utm_medium=email&utm_campaign=DailyHeadlines&utm_source=WC&eun=g99985d0r&userid=99985&email=avivalev-ari@alum.berkeley.edu&mu_id=5099207 Action Points This study […]

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Why Blood Clots Are a Major Problem in Severe COVID-19

Posted in Biomarkers: Inflammation, Coronavirus Gene Expression, COVID-19, Immune-Mediation (independent immunopathology: lung and reticuloendothelial system), Population Health Management, Genetics & Pharmaceutical, SAR-Cov-2 a vasculotropic (blood vessels) RNA Virus, SARS-CoV-2, SARS-COV2 Hijacking the Complement and Coagulation Systems, Treatment Protocols for COVID-19, Virus Infective Acute Respiratory Syndrome: SARS-CoV, tagged , , , , , , , , on September 1, 2020| Leave a Comment »


Why Blood Clots Are a Major Problem in Severe COVID-19 Reporter: Aviva Lev-Ari, PhD, RN   Clotting in uninjured blood vessels is a common occurrence in hospital patients, especially those in the intensive care unit. In a July report in the journal Blood, Al-Samkari and colleagues found that nearly 10 percent of 400 people hospitalized for Covid-19 developed […]

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WordCloud Visualization of LPBI’s Top Sixteen Articles on CANCER in eight categories and by Views at All Time and their Research Categories in the Ontology of PharmaceuticalIntelligence.com

Posted in Cancer and Current Therapeutics on July 30, 2020| 7 Comments »


WordCloud Visualization of LPBI’s Top Sixteen Articles on CANCER in eight categories and by Views at All Time and their Research Categories in the Ontology of PharmaceuticalIntelligence.com Curator: Stephen J. Williams, PhD and WordCloud Producers: Daniel Menzin, Noam Steiner-Tomer, Zach Day, Ofer Markman, PhD and Aviva Lev-Ari, PhD, RN Introduction (From Cancer Volume 1): Cancer […]

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“Repurposing” Off-patent Drugs offers big hopes of New Treatments

Posted in Drug Delivery Platform Technology, Drug Development Process, tagged , , , , on June 29, 2020| Leave a Comment »


“Repurposing” Off-patent Drugs offers big hopes of New Treatments Reporter: Irina Robu, PhD Given the substantial costs and the slow pace of drug discovery and development, repurposing old drugs has become a practice, partly because it involves the use of already developed compounds. Yet, there is lack of clinical interest in repurposing off patent drugs. […]

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Live Notes, Real Time Conference Coverage AACR 2020 #AACR20: Tuesday June 23, 2020 Noon-2:45 Educational Sessions

Posted in AI-assisted Cardiac MRI, Anaerobic Glycolysis, Artificial Intelligence - Breakthroughs in Theories and Technologies, Artificial Intelligence - General, Artificial Intelligence Applications in Health Care, Big Data, Big Data & Analytics, BioBanking, Biochemical pathways, Biological Networks, Gene Regulation and Evolution, Breast Cancer - impalpable breast lesions, Cancer - General, Cancer and Current Therapeutics, CANCER BIOLOGY & Innovations in Cancer Therapy, Cancer Genomics, Cancer Informatics, cancer metabolism, Cancer Prevention: Research & Programs, Curation, Data Science, Deep Learning in Pathology, Intelligent Information Systems, Metabolic Immuno-Oncology, Metabolism, Oxidative phosphorylation, Phosphorylation, REAL TIME Conference Coverage Twitter's Hashtags and Handles per Presentation/session, Scientific & Biotech Conferences: Press Coverage, Scientific Publishing, Scientist: Career considerations, Signaling, Transformative Technologies in Healthcare, tumor microenvironment, tagged , , , , , , , , , , , , , , , , , , , , , , , , , , on June 23, 2020| 1 Comment »


Live Notes, Real Time Conference Coverage AACR 2020: Tuesday June 23, 2020 Noon-2:45 Educational Sessions Reporter: Stephen J. Williams, PhD Follow Live in Real Time using #AACR20 @pharma_BI @AACR Register for FREE at https://www.aacr.org/   Presidential Address Elaine R Mardis, William N Hait DETAILS Welcome and introduction William N Hait   Improving diagnostic yield in pediatric cancer precision […]

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