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The Promise of Low-Dose Aspirin on Longevity in the Geriatric Population: No Effect on Outcomes in the US and Australia Reporter: Aviva Lev-Ari, PhD, RN UPDATED on 10/17/2018 https://www.nejm.org/doi/full/10.1056/NEJMoa1800722 Effect of Aspirin on Disability-free Survival in the Elderly ORIGINAL ARTICLE Effect of Aspirin on Disability-free Survival in the Healthy Elderly J.J. McNeil and Others      […]

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UPDATED on 7/17/2016 Aspirin Fails to Prevent Cardiovascular Events in High-Risk Patients Significant bleeding risk may outweigh any benefit Aspirin Fails to Prevent Cardiovascular Events in High-Risk Patients   Aspirin Advocate vs Skeptic: Any Common Ground? Source: login.medscape.com See on Scoop.it – Cardiovascular Disease: PHARMACO-THERAPY

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Intracranial Vascular Stenosis: Comparison of Clinical Trials: Percutaneous Transluminal Angioplasty and Stenting (PTAS) vs. Clot-inhibiting Drugs: Aspirin and Clopidogrel (dual antiplatelet therapy) – more Strokes if Stenting   Reporter: Aviva Lev-Ari, PhD, RN   UPDATED on 8/5/2018 Clopidogrel plus aspirin bests aspirin alone for CV event reduction: Cochrane Source: JAMA, Published online July 26, 2018. doi:10.1001/jama.2018.9641 Curated […]

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Platelet Endothelial Aggregation Receptor-1 (PEAR1) Gene to be most strongly associated with Dual Antiplatelet Therapy Response: Genetic Determinants of Variable Response to Aspirin (alone and in combination with Clopidogrel) Reporter: Aviva Lev-Ari, PhD, RN 4 Genetic Variation in PEAR1 is Associated with Platelet Aggregation and Cardiovascular Outcomes Joshua P. Lewis1, Kathleen Ryan1, Jeffrey R. O’Connell1, Richard B. Horenstein1,Coleen M. Damcott1, Quince […]

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Reporter: Aviva Lev-Ari, PhD, RN Aspirin Use, Tumor PIK3CA Mutation, and Colorectal-Cancer Survival N Engl J Med 2012; 367:1596-1606 October 25, 2012DOI: 10.1056/NEJMoa1207756 BACKGROUND Regular use of aspirin after a diagnosis of colon cancer has been associated with a superior clinical outcome. Experimental evidence suggests that inhibition of prostaglandin-endoperoxide synthase 2 (PTGS2) (also known as cyclooxygenase-2) by aspirin […]

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Aspirin a Day Tied to Lower Cancer Mortality Reporter: Aviva Lev-Ari, PhD, RN Aspirin a Day Tied to Lower Cancer Mortality Download Complimentary Source PDF  By Nancy Walsh, Staff Writer, MedPage Today Published: August 10, 2012 Reviewed by Zalman S. Agus, MD; Emeritus Professor, Perelman School of Medicine at the University of Pennsylvania  http://www.medpagetoday.com/HematologyOncology/OtherCancers/34149?utm_content=&utm_medium=email&utm_campaign=DailyHeadlines&utm_source=WC&eun=g99985d0r&userid=99985&email=avivalev-ari@alum.berkeley.edu&mu_id=5099207 Action Points This study […]

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Why Blood Clots Are a Major Problem in Severe COVID-19 Reporter: Aviva Lev-Ari, PhD, RN   Clotting in uninjured blood vessels is a common occurrence in hospital patients, especially those in the intensive care unit. In a July report in the journal Blood, Al-Samkari and colleagues found that nearly 10 percent of 400 people hospitalized for Covid-19 developed […]

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WordCloud Visualization of LPBI’s Top Sixteen Articles on CANCER in eight categories and by Views at All Time and their Research Categories in the Ontology of PharmaceuticalIntelligence.com Curator: Stephen J. Williams, PhD and WordCloud Producers: Daniel Menzin, Noam Steiner-Tomer, Zach Day, Ofer Markman, PhD and Aviva Lev-Ari, PhD, RN Introduction (From Cancer Volume 1): Cancer […]

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“Repurposing” Off-patent Drugs offers big hopes of New Treatments Reporter: Irina Robu, PhD Given the substantial costs and the slow pace of drug discovery and development, repurposing old drugs has become a practice, partly because it involves the use of already developed compounds. Yet, there is lack of clinical interest in repurposing off patent drugs. […]

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Live Notes, Real Time Conference Coverage AACR 2020 #AACR20: Tuesday June 23, 2020 Noon-2:45 Educational Sessions


Live Notes, Real Time Conference Coverage AACR 2020: Tuesday June 23, 2020 Noon-2:45 Educational Sessions Reporter: Stephen J. Williams, PhD Follow Live in Real Time using #AACR20 @pharma_BI @AACR Register for FREE at https://www.aacr.org/   Presidential Address Elaine R Mardis, William N Hait DETAILS Welcome and introduction William N Hait   Improving diagnostic yield in pediatric cancer precision […]

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