Next-generation Universal Cell Immunotherapy startup Adicet Bio, Menlo Park, CA is launched with $51M Funding by OrbiMed
Reporter: Aviva Lev-Ari, PhD, RN
Updated on 4/19/2022
https://www.adicetbio.com/pipeline/#pipeline
https://kvgo.com/2022-oncology-conference/adicet-bio-inc-feb
Adicet Bio, Inc. (formerly resTORbio, Inc. (resTORbio)), together with its subsidiaries, (the Company) is a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for cancer. The Company is advancing a pipeline of off-the-shelf gamma delta T cells, engineered with chimeric antigen receptors (CARs) and T cell receptor-like antibodies to enhance selective tumor targeting, facilitate innate and adaptive anti-tumor immune response, and improve persistence for durable activity in patients. The Company’s approach to activate, engineer, and manufacture allogeneic gamma delta T cell product candidates derived from the peripheral blood cells of unrelated donors allows it to generate new product candidates in a rapid and cost efficient manner. The Company was incorporated in November 2014 in Delaware. The principal executive offices are located in Boston, Massachusetts. The Company also has another office in Menlo Park, California. Adicet Bio, Inc. (when referred to prior to the Merger (as defined below), (Former Adicet)) was incorporated in November 2014 in Delaware and was headquartered in Menlo Park, CA. Adicet Bio Israel Ltd. (formerly Applied Immune Technologies Ltd.) (Adicet Israel) is a wholly owned subsidiary of Former Adicet and is located in Haifa, Israel. Adicet Israel was founded in 2006. During 2019, Former Adicet consolidated its operations, including research and development activities, in the United States and as a result substantially reduced its operations in Israel.
They had a MERGER,
Merger with resTORbio
On September 15, 2020, the Company completed the Merger pursuant to the Merger Agreement (the Effective Time). In connection with the Merger, and immediately prior to the Effective Time, resTORbio effected a reverse stock split of its common stock at a ratio of 1-for-7 (the Reverse Stock Split). Also, in connection with the Merger, the Company changed its name from “resTORbio, Inc.” to “Adicet Bio, Inc.” (the Name Change), Former Adicet changed its name from “Adicet Bio, Inc.” to “Adicet Therapeutics, Inc.” and the business conducted by the Company became primarily the business, which was previously conducted by Former Adicet, which is a biotechnology company discovering and developing allogeneic gamma delta T cell therapies for cancer and other diseases.
an IPO, and
they are Traded on NASDAC – no profits !!!!!!!!!
Updated on 1/27/2016
On 1/27/2016 Adicet Bio announced the acquisition of Applied Immune Technologies (AIT)
Applied Immune Technologies (AIT) was acquired by Adicet, 1/27/2016.
AIT is a drug development company specializing in T-Cell Receptor-Like (TCRL) antibodies that are targeted to intracellular-derived peptides for a variety of therapeutic and diagnostic applications. AIT is also focused on identification and validation of novel therapeutic targets.
Therapeutic Antibodies
AIT’s core technology platforms encompass the identification and validation of novel MHC-based targets, as well as development of therapeutic Human Recombinant T-Cell Receptor-Like (TCRL) antibodies with the unique ability to bind with these intracellular peptide/MHC complexes with the specificity of cytotoxic T-cell killer cells.
AIT’s technologies enable the generation of a rich pipeline of therapeutic TCRL antibodies for intracellularly-derived, disease-specific targets which normally are not accessible to conventional antibodies. TCRL antibodies also have diagnostic applications in vaccine design, validation and monitoring, as well as analysis of antigen presentation in disease.
Immune System Explained
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http://www.tcrl.co.il/home/doc.aspx?mCatID=57466Publications
AIT – Technology
TCRL™ Antibodies |
AIT’s innovative solution is a platform technology for the development of human recombinant T-Cell Receptor-Like (TCRL) antibodies capable of targeting intracellular-derived peptides. These 3rd generation antibodies combine the advantages of both arms of the immune system. They are capable of binding to targets with high affinity and specificity like conventional antibodies. In addition, they can recognize and bind to intracellular-derived peptides presented on the MHC complex with the same degree of specificity as T cells, but without being limited by the regulatory mechanisms imposed on T cells. TCRL antibodies enable us to identify and validate intracellular-expressed disease-specific targets and make them available for cell surface targeting. AIT’s platform technology further enables the generation of highly specific therapeutic antibodies against these intracellular-derived targets, which can bind to them on the cell surface and kill the diseased cells only, without effecting healthy cells. Thus, disease-specific targets that are expressed inside diseased cells are transformed into targets that can be recognized by soluble antibodies on the cell surface. This breakthrough harnesses the power of the cellular arm of the immune system to attack diseased cells with soluble, readily made human monoclonal antibodies. Distinct from conventional monoclonal approaches that only attack cell surface-associated proteins, AIT’s TCRL technology addresses the far more abundant intracellular proteome. The combination of these features opens up entirely new vistas for the development of highly specific 3rdgeneration antibodies for the treatment of cancer, viral, and autoimmune diseases. SOURCE http://www.tcrl.co.il/home/doc.aspx?mCatID=27142
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Publications
Makler, O., Oved, K., Netzer, N., Wolf, D., Reiter, Y. Direct visualization of the dynamics of antigen presentation in human cells infected with cytomegalovirus revealed by antibodies mimicking TCR specificity. Eur. J. Immunol. 40: 1552-1562, 2010.
Klechevsky, E., Flamar, A.L., Cao, Y., Liu, M., Thompson-Snipes, L., O’Bar, A., Zurawski, S., Reiter, Y., Zurawski, G., Banchereau, J. Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR. Blood 116:1685-97, 2010.
Dahan, R., Tabul, M., Chou, Y.K., Meza-Romero, R., Andrew, S., Ferro, A.J., Burrows, G.G., Offner, H., Vandenbark, A.A., Reiter, Y. TCR-like antibodies distinguish conformational and functional differences in auto-reactive idiotopes present on two vs. four-domain MHC class II/peptide complexes. Eur. J. Immunol. 41:1465-79,2011.
Dahan, R, Reiter, Y. T-cell-receptor-like antibodies – generation, function and applications. Expert Rev Mol Med. 14:e6, 2012.
Noy, R., Epel, M., Haus-Cohen, M., Klechevsky, E., Makler, O., Michaeli, Y., Denkberg, G., Reiter, Y. T-cell receptor-like antibodies: novel reagents for clinical cancer immunology and immunotherapy. Exp. Rev. Anticancer Ther. 5(3) 2005.
Michaeli, Y., Sinik, K., Cohen, M., Reiter, Y:. Protein Instability and Aberrant Intracellular Processing of Tyrosinase Lead to High Presentation of HLA-A2/Tyrosinase Complexes on the Surface of Melanoma Cells. Eur. J. Immunol. In press 2012.
SOURCE
http://www.tcrl.co.il/home/doc.aspx?mCatID=27120
Next-generation immunotherapy startup Adicet is launched with $51M Funding by OrbiMed
Reporter: Aviva Lev-Ari, PhD, RN
Aya Jakobovits, former founder and CEO of Kite Pharma and current venture partner at OrbiMed, is heading up a new, next-gen immunotherapy startup – backed by an impressive $51 million Series A.
The Bay Area upstart, called Adicet Bio, is keeping very quiet about its underlying platform. Jakobovits emphasized in a phone interview, however, that the platform is meant to develop “universal immune cell therapy” – meaning it should be broadly applicable for a number of diseases, including cancer, autoimmune disease and inflammation.
It’s launching with news of an acquisition, however: Adicet just bought Israeli immunotherapy company Applied Immune Technologies, which focuses on the intracellular proteome.
“There’s a very good correlation between AIT and Adicet,” Jakobovits said.
AIT develops T-Cell Receptor-like antibodies that are targeted, through the Major Histocompatibility Complex (MHC), toward disease-linked peptides in cells. Adicet’s plan is to generate monoclonal antibodies that have affinity and high specificity to this MHC complex, she said.
Jakobovits said there’s no correlation or link between Kite Pharma and Adicet – in technology or in business dealings.
The financing round was led by OrbiMed with participation from Novartis Venture Fund and Pontifax.
SOURCE
Adicet Bio Announces Closing of $51 Million Series A Financing and Acquisition of
Applied Immune Technologies
Menlo Park, CA (January 27, 2016): Adicet Bio, Inc. (“Adicet”), a biopharmaceutical company focused on the development of next-generation cell immunotherapies, announced today that it closed a $51 million Series A financing. Adicet also announced the acquisition of Applied Immune Technologies, Ltd. (“AIT”), an Israel-based company that develops immunotherapies directed to the intracellular proteome.
The financing was led by OrbiMed and also included Novartis Venture Fund and Pontifax.
“These significant financial resources will allow Adicet to progress its universal immune cell therapy (“uICT”) platform technology and related products and advance AIT’s programs and product pipeline,” said Aya Jakobovits, Ph.D., Founder, President and Chief Executive Officer of Adicet. “AIT’s technologies, capabilities, and intellectual property highly complement those of Adicet and position the combined company to become a leader in next-generation immunotherapy products for cancer and other indications.
Adicet was founded by Aya Jakobovits and OrbiMed. Previously, Dr. Jakobovits served as the President and founding CEO of Kite Pharma, Inc. Before joining Kite Pharma, she served as Executive Vice President, Head of Research and Development at Agensys, Inc., which became an affiliate of Astellas Pharma Inc. in a deal valued at up to $537 million. Before its acquisition, she served as Agensys’ Senior Vice President, Technology and Corporate Development and Chief Scientific Officer. Prior to Agensys, Dr. Jakobovits served as the Director, Discovery Research and Principal Scientist at Abgenix, Inc., which was spun out of Cell Genesys, Inc. and based on the XenoMouse® technology developed under her leadership. Abgenix was acquired by Amgen Inc. for $2.2 billion.
AIT specializes in generating and developing T-Cell Receptor-Like (“TCRL™”) antibodies with high affinity and specificity to disease-specific intracellular peptides presented on the cell surface by the major histocompatibility complex (“MHC”). AIT also established Epitarget™, a proprietary technology to identify and validate novel disease-specific peptide targets. AIT technology is based on work by Prof. Yoram Reiter, a world leader in the research of immunotherapies directed to the intracellular proteome. AIT will continue its operations in Israel as Adicet’s wholly-owned subsidiary.
Following the financing and acquisition, the Adicet Board of Directors will include Jonathan Silverstein and Carl Gordon, General Partners and Co-Heads of Global Private Equity at OrbiMed, Aya Jakobovits, Florent Gros, Managing Director at Novartis Venture Fund, and Erez Chimovits, Managing Director at OrbiMed Israel.
“We are excited to join forces again with Aya, a prominent figure in the field of immunotherapy with a track record of growing successful biotechnology companies,” said Carl Gordon.
“We look forward to building a leading immunotherapy company,” said Jonathan Silverstein. “The AIT acquisition expands Adicet’s platform technologies and its product pipeline.”
About Applied Immune Technologies, Ltd.
Applied Immune Technologies Ltd. (“AIT”) pioneered and advanced the generation and development of TCRLs for therapeutic and diagnostic applications in cancer, inflammation, autoimmune, and infectious diseases. AIT’s TCRLs are directed to disease-specific peptide-MHC complexes and are aimed at delivering potent payloads specifically to the diseased cells. AIT’s pipeline includes TCRLs directed to different disease indications. AIT also established a robust and proprietary technology for identification and validation of novel MHC-based targets. AIT was founded in 2006 by Prof. Yoram Reiter, Head of the Laboratory of Molecular Immunology at the Technion, Israel Institute of Technology, and Mira Peled-Kamar, Ph.D., AIT Chief Executive Officer. AIT is located in Haifa, Israel.
About Adicet Bio, Inc.
Adicet Bio, Inc. is a privately held, pre-clinical stage biotechnology company engaged in the design and development of cutting-edge immunotherapies for cancer and other disease indications, with a focus on novel universal immune cell therapies (uICT). Adicet Bio is located in Menlo Park, California.
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Contact:
Aya Jakobovits, Ph.D.
President and Chief Executive Officer
Adicet Bio, Inc.
Tel 310.990.3832
ajakobovits@adicetbio.com
For Media:
Joan Kureczka
Kureczka/Martin Associates
Tel 415.821.2413
Mobile 415.690.0210
joan@kureczka-martin.com
SOURCE
ATI Management
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Dr. Denkberg leads AIT’s TCRL development team. A graduate of the Technion’s Faculty of Biology, she worked with Prof. Yoram Reiter on the design and construction of the single-chain MHC molecules and was the first in the group to isolate TCRL antibodies from both immunized and naïve phage-display libraries. Through the years Dr. Denkberg has mastered a variety of molecular immunology, cellular immunology and molecular biology techniques and has become an expert in design, application, and characterization of TCRL antibodies. Dr. Denkberg is the author of 16 scientific papers related to the TCRL technology in leading peer-reviewed journals.
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