Leaders in Pharmaceutical Business Intelligence (LPBI) Group

11/19/2015 noon Keynote Genomics England, Innovators in Personalized Medicine, Value of Care @AZ, 11th Annual Personalized Medicine Conference, November 18-19, 2015, Harvard Medical School

Reporter: Aviva Lev-Ari, PhD, RN

Live Press Coverage in REAL TIME

Aviva Lev-Ari, PhD, RN

Director & Founder, Leaders in Pharmaceutical Business Intelligence, Boston

Co-Founder, GDE

12:o0 noon – Keynote Speaker

Genomics England

• UK is uniquely positioned
• Medicine new movement: NHS 65th Anniversary Celebration, July 2013 by Genomics England announced by Secretary of State for Health
• Patient Community Support, Wearables and Consumer Health Remote consulting Elective Care Out of Hospital Care
• network support applications
• Cyber security and consents management
• National Repository
• 100,000 Genomes Projects – A pioneering Step in the UK towards Routine Genomics Medicine
• 2012 in UK: National Information Board Strategy

1. Heterogeneous population
2. National Health system to deliver
3. Excellent Genomics research in the UK
4. Cornerstone decisions

• rare inherited disease
• Transformation of the Medical practice: CHANGE in Clinical Data Flow:
• Partners: Sequencing: Illumina1 was selected, Welcome Trust/Sanger
• GMC responsibility: Concent, dna extraction, biobank, sequence, variant calling, interpretation, sharing results with client, decision on treatment, Patient in Clinic for a Protocol
• Achieve AT rich and GC rich
• OPTIMUM combination of choices to deliver the best Genome
• Experimental Pathway: upstream
• Clinical Interpretation Partnerships: 30 diseases 2500 Clinicians
• All IP held by Genomics England is available for licensing
• Rare diseases clinical data models for a CATALOGUE: Disease -specific element vs shared core elements
• Commercial Partnerships: Pharma and BioTech, Bioinformatics and ANalytics
• GENE Consorsium: Big Pharma
• Data Architecture Schematics: Genomics Data Store VCF and BAMs
• data interpretation: data sets Analysis Tools and Embassy done following Cleansing
• Other aspects: Media Coverage The DNA of a Nation: Nature, August, Genomics England – Precision Medicine can be done at a National level.
• Interpretation Partnerships: Complicated,

12:30 p.m. – Bag Lunch

Bag lunch with open seating for all conference attendees

1:30 p.m. – Panel Discussion

Innovators in Personalized Medicine

The movement in any field of medicine is dependent upon the organizations and its leaders. There are a large number of innovative ideas that are transforming the way we provide healthcare to patients and in this panel we will hear examples of how successful companies are built and how some large companies are increasing their investments in personalized medicine..

• identify a mutation to be a candidate for therapeutics
• Ten years to secure one disease
• one FDA approval caused stock to increse TEN folds
• molecular, RNA, DNA, Protein targeted to therapeutics
• genomics information, EMR for sequencing
• DB that you can trust, Geisinger in PA sequencing the entire HealthCare System of One Institution
• NIH needs to do more translational not only basic research
• Champion inside the organization needed to foster new partnerships
• CEO worries about the cost of R&D, Insurance does not care about investment in Prevention – NO profit in it
• Elevate the discussion to cover all aspects
• Geisinger: FULL INTEGRATION in one system vs adversary parties

AUDIENDCE

• Genomics Diagnostics: CMS, National CMS, Roche applies Hybrid model, incentive organizations to collaborate and solve reimbursement for genomics testing
• Quest Diagnostics works with Insurance payers worst than dealing with CMS
• Reimbursement: Should it be by disease or all along the treatment cycle
• AstraZeneca BUDGET OF R&D INCREASED EACH YEAR AND IS AT RECORD EVER HIGH IN COMPANY’S HISTORY

2:30 p.m. – Keynote Speaker

Opportunities in Personalized Medicine: Redefining the Value of Care

3:00 p.m. – Closing Remarks

• UK Model – On eNation and the role of Genomics
• Foundation Medicine paradigm in Cancer diagnostics

Team recognition and PMC – team members

– See more at: http://personalizedmedicine.partners.org/Education/Personalized-Medicine-Conference/Program.aspx#sthash.O4Znb9kq.dpuf

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