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Research on inflammasomes opens therapeutic ways for treatment of rheumatoid arthritis

Reporter: Larry H. Bernstein, MD, FCAP

One of the processes accounted for by inflammasomes is the production of interleukin-1, a protein with an important role in inflammatory reactions. Stopping the effects of interleukin-1 resulted in a cure for the mice. In this manner, Vande Walle and Lamkanfi demonstrated that the mouse model is perfectly suitable for studying the correlation between inflammasomes and RA.

RA is a syndrome rather than a single disease
Previous research has already demonstrated that other proteins in our immune system – such as TNF and IL-17 – could possibly play a role in RA
We could evolve towards a more personalized approach for RA