2,000-year-old herb regulates autoimmunity
What we are learning from extraction of natural products is astounding
Researchers discover molecular secrets of ancient Chinese herbal remedy
BOSTON, Mass. (February 12, 2012)—For roughly two thousand years, Chinese herbalists have treated Malaria using a root extract, commonly known as Chang Shan, from a type of hydrangea that grows in Tibet and Nepal. More recent studies suggest that halofuginone, a compound derived from this extract’s bioactive ingredient, could be used to treat many autoimmune disorders as well. Now, researchers from the Harvard School of Dental Medicine have discovered the molecular secrets behind this herbal extract’s power.
It turns out that halofuginone (HF) triggers a stress-response pathway that blocks the development of a harmful class of immune cells, called Th17 cells, which have been implicated in many autoimmune disorders.
“HF prevents the autoimmune response without dampening immunity altogether,” said Malcolm Whitman, a professor of developmental biology at Harvard School of Dental Medicine and senior author on the new study. “This compound…
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The interesting mechanism discovered is that HF inhibits proline incorporation into proteins, thus many of the effects on collagen. I wonder if HF is actually has a quinone intermediate and actually there is competition for proline incorporation. Meaningful study as they did in depth analysis of mechanism. However I wonder how similar quinine, (chinchona, used in tropics for malaria) is similar to HF. Would be interesting to see if a similar mechanism of action.