flavonoids are receiving a lot of attention for neutraceutical potential. They were not at all in the traditional landscape for nutrition.
30 Jan 2012
Luteolin is a flavonoid commonly found in fruit and vegetables. This compound has been shown in laboratory conditions to have anti-inflammatory, anti-oxidant and anti-cancer properties but results from epidemiological studies have been less certain. New research published in BioMed Central’s open access journal BMC Gastroenterology shows that luteolin is able to inhibit the activity of cell signaling pathways (IGF and PI3K) important for the growth of cancer in colon cancer cells.
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As mentioned in the article, this may have been a transient effect on transcription. Of course much more work is needed and healthy diets are always recommended however I would be cautious to the authors about the claims about chemoprevention. These type of studies require a large number of subjects and are very complicated, often leading to nothing more than inconclusive, or sometimes, confusing results. The selenium-Vitamin E prostate cancer prevention trial did not produce any meaningful results as well as the Vitamin A lung cancer chemoprevention trials. In europe, where these type of studies can recruit massive number of subjects, fenretinide, a synthetic retinoid, showed no effect against onset of secondary breast cancer (although there appeared an effect on ovarian cancer incidence although the numbers 0 out of 6 patients were too small to be conclusive).