Track 11 Collaboration and Externalization in R&D @ BioIT World, April 30, 2014 Seaport World Trade Center, Boston, MA
Reporter: Aviva Lev-Ari, PhD, RN
Collaboration and Externalization in R&D
4:00 Co-Presentation: Informatics Paradox: Separating and Collaborating in Life Science
Sarah Blendermann, Senior Director, Chemistry & Pharmacology, Business
Technology, Pfizer
Rick Somes, Senior Director, Acquisitions, Divestitures and Restructuring
R&D Business Technology, Pfizer
The organization was running operations and discovery while separating data and systems. Collaboration and segregation were key components of
the informatics required to successfully meet an IPO timeline. A long-term collaboration agreement means ties between the organizations will remain,
requiring longer-term technical solutions for granular security, collaboration, and data sharing.
In REAL TIME
Possibilities:
Sell a sunsidiary for Animal health
IPO
Spin off a subsidiary
Key issues for R%D – 70% of applications, 800 applications between Whole Pfizer and Animal Health.
COLLABORATE
Build a Plan
Thinks to consider 0 Have a documen: Data, people, IT resources
- Application Separation
- License Separations – Vendors: SAS, 800 applications in the postfolio
- Data sepation:
- Compound Inventory – Legal Agreements
- FDA Library
- sales complexity
- IPO complexity -Hard
Begin Separation
- IPO day
- Separation day Zoetis vs. Pfizer
- Application Separation: Human Health vs Animal Health
- Transition Services Agreement – to support shared Applications
- Data Separations Research Commom Compound
- IP, who own experimental research data
- Encumbrances: Collaborations
- Legal agreements
- Collaborations Application to share data
Two separate companies, Partnering on Enchanting future PROVENANCE Issues
4:30 Towards the Intelligent and Automated Analytical Laboratory
Dave Hartsough, Ph.D., Executive Director, Sites, Benchtop, & Validation R&D Informatics, Amgen
This presentation will provide an update on the progress of the Allotrope Foundation towards delivering an open Framework solution for managing analytical data throughout its lifecycle and will include details on the deliverables, timelines, and results from completed proof-of-concept applications based upon the initial proposal and analysis presented in 2013.
Dave Hartsough in REAL TIME
Data id MOST valuable asset
If 3% error rate it addds 30% more cost
EMPLOYEES are the most valuable not data
ALLOTROPE: A foundation
- Subject matter experts
- Osthus – s Gernam company
- Secretairiate
SW incomplete, no standard formats, incompatible Metadata
Effects: Need for a Framework
Solution Automated documents
- open documents standard – existing standards
- Metadata Repository
- Reusable SW componenets
Ready for archiving
Proof-of-Concept applications (2014)
PoC Instruent SW Integration, PoC Archive, Metadata repository, PoC Viewer
Heading up toward: Being SOurce agnostict
- Commercial ELN/LIMS,
- Commercial Archive
- Commercial Viewer
GOAL: Reduce cost of interaction with CRO
Example: One instance of one workflow: 20,000 hours per year saving, increasing accuracy, quality of data
First PoC deployed to one of member company
BENEFITS OF BEING A MEMBER IN THIS INTERNATIONAL CONSORTIUM
Instrument & software Vendors
http://partners.alllotrope.org
Regulatory engagement FDA Liaison to be assign to work wiht the Consorsium.
Access data complexity – reduced
Framework is based on dtandard
ROI
5:00 Growing our Innovation Capability from the Inside-Out: AstraZeneca’s Journey to a New a Way of Working
Scott Wilkins, Ph.D., Enterprise Innovation Director, AstraZeneca
Scott Wilkins in REAL TIME
$4 billion spent on R&D every year
25 Billion in Sales
Partnering and collaborations are KEY
21 century- NETWORKS are key to survival
Use R&D resources and Collaborations
2010 – R&D Culture Initiatives – Professional skills, communications, grow collaborative behaviors
2011 – Evaluated and Piloted R&D Collaborations tools Globally enterprise -wide R&D
2012 0 Innovation Capabilities: Culture, technology, partners, Processes
Information Pyramid
InnoCENTIVE -consuting with NASA
- iSOLE Coach
- Challenge Owner
- Solver evaluation & Award
2012 – 5,000 participants in Challenges launched, 500 ideas, $1 million Awarded to Winners
Enterprise Collaboration
OUTCOMES: Going to AstraZeneca OPEN Innovations 10,000 Scientists around the glovbr
- New molecule Profiling
- Novel Disease Indications for AstraZeneca Competition
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