Leaders in Pharmaceutical Business Intelligence (LPBI) Group

Collaborations and Open Access Innovations – CHI, BioIT World, 4/29 – 5/1/2014, Seaport World Trade Center, Boston

Reporter: Aviva Lev-Ari, PhD, RN

 

Track 11 explores best practices in collaboration and information sharing that helps to drive progress in translational research. Case studies will be presented to show new insights on key drivers, technology innovations, collaboration platforms, open-source frameworks, and other factors that are managing analytical data and empowering transformative changes through translation. Additional topics to be covered include portals (website, research, collaboration) and their applications, data liquidity, and technical and cultural obstacles.

Final Agenda

 

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TUESDAY, APRIL 29

 

 

2:00 – 7:00 pm Main Conference Registration

4:00 Event Chairperson’s Opening Remarks

Cindy Crowninshield, RD, LDN, Conference Director, Cambridge Healthtech Institute

 

 

5:00 – 7:00 Welcome Reception in the Exhibit Hall with Poster Viewing

iPad® mini & Bose® QuietComfort 15 Noise Cancelling Headphones Raffle! Drawing held at 6:30pm!*

 

*Apple® & Bose® are not sponsors or participants in this program.

 

WEDNESDAY, APRIL 30

7:00 am Registration Open and Morning Coffee

8:00 Chairperson’s Opening Remarks

Phillips Kuhl, Co-Founder and President, Cambridge Healthtech Institute

 

 

9:00 Benjamin Franklin Award & Laureate Presentation

9:30 Best Practices Awards Program

9:45 Coffee Break in the Exhibit Hall with Poster Viewing

 

COLLABORATING IN CHRONIC AND RARE DISEASES 

10:50 Chairperson’s Remarks

Marcia Kean, Chairman, Strategic Initiatives, Feinstein Kean Healthcare

11:00 PANEL DISCUSSION: Data Liquidity: New “Surge” in the War against Cancer, Diabetes and MS

Marcia Kean, Chairman, Strategic Initiatives, Feinstein Kean Healthcare

Gwen Darien, Executive Vice President, Programs and Services, Cancer Support Community

Robert McBurney, Ph.D., neuroscientist; CEO, Accelerated Cure Project for MS

Kenneth Buetow, Ph.D., Director of Computational Sciences and Informatics, Complex Adaptive Systems Initiative (CASI), Arizona State University

Dave King, Founder and CEO, Exaptive, Inc.

Data that could be applied to fuel biomedical research has been siloed, inaccessible, and often incomprehensible across disciplines. New initiatives, often driven by patients, are demanding standards-based collection of data that can be facilely integrated, analyzed and shared. The Data Liquidity Coalition is a collaboration comprised of a wide spectrum of stakeholders in the biomedical community – including providers, payers, patients, researchers and others –who are deeply committed to actualizing a common vision of data liquidity to achieve personalized medicine. This panel of Coalition members will present three collaborative projects underway to combat killer and chronic diseases. Each project puts patients at the center, and uses open source technology to enable the seamless usage of data from multiple sources to accelerate basic, translational, clinical and psychosocial research, as well as to lay the groundwork for a national system of data liquidity in biomedicine.

12:00 pm Sponsored Presentations (Opportunities Available)

12:30 Luncheon Presentations (Sponsorship Opportunities Available) or Lunch on Your Own

1:50 Chairperson’s Remarks

1:55 Collaborating in Rare Diseases through Technology

Alex Sherman, Director, Strategic Development and Systems, Neurological Clinical Research Institute, Massachusetts General Hospital

Rare diseases have to self-organize to become attractive to pharma/biotech industry. Collaborative technology and methodology allow information to be aggregated and harmonized from heterogeneous sources, including patient registries, Electronic Health Records, biorepositories, and clinical and research databases. Global Patient Identifier helps to link it all together. Evolving crowd-sourcing and crowd-funding initiatives allow multiply number of people participating in medical research and data analyses.

2:25 Accelerating Rare and Chronic Disease Research with Transparent Informatics

Alexander Wait Zaranek, Ph.D., Research Fellow in Genetics, Harvard Catalyst at Harvard Medical School

2:55 Sponsored Presentation (Opportunity Available)

3:10 Accelrys ScienceCloud: A Hosted Strategies for Collaborative R&D

Matt Hahn, Ph.D., CTO, Accelrys

The life sciences industry has been undergoing dramatic changes and effective global collaboration has become a key success factor in this new age. Accelrys is providing a hosted and comprehensive solution stack for externalized, collaborative research for pharma/biotech and CROs to address these new challenges.

3:25 Refreshment Break in the Exhibit Hall with Poster Viewing

 

COLLABORATION AND EXTERNALIZATION IN R&D 

4:00 Informatics Paradox: Separating and Collaborating in Life Science

Sarah Blendermann, Senior Director, Chemistry & Pharmacology, Business Technology, Pfizer

The organization was running operations and discovery while separating data and systems. Collaboration and segregation were key components of the informatics required to successfully meet an IPO timeline. A long-term collaboration agreement means ties between the organizations will remain, requiring longer-term technical solutions for granular security, collaboration, and data sharing.

4:30 Towards the Intelligent and Automated Analytical Laboratory

Dave Hartsough, Ph.D., Executive Director, Sites, Benchtop, & Validation R&D Informatics, Amgen

This presentation will provide an update on the progress of the Allotrope Foundation towards delivering an open Framework solution for managing analytical data throughout its lifecycle and will include details on the deliverables, timelines, and results from completed proof-of-concept applications based upon the initial proposal and analysis presented in 2013.

5:00 Sponsored Presentations (Opportunities Available)

5:30 – 6:30 Best of Show Awards Reception in the Exhibit Hall

 

THURSDAY, MAY 1

7:00 am Registration Open

7:00 Breakfast Presentation (Sponsorship Opportunity Available) or Morning Coffee

8:00 Chairperson’s Opening Remarks

Kevin Davies, Ph.D., Vice President Business Development & Publisher C&EN, American Chemical Society; Founding Editor, Bio-IT World

 

 

10:00 Coffee Break in the Exhibit Hall and Poster Competition Winners Announced

 

COLLABORATIVE APPROACHES TO CLINICAL DATA 

10:30 Chairperson’s Opening Remarks

10:35 PANEL DISCUSSION: Forming a Collaborative Approach to Develop a Data and Technology Blueprint

Muzafar Mirza, Director, Information Strategy and Analytics, Clinical Informatics and Innovation, Pfizer, Inc.

Georgina Wood, Global Head, Technology Innovations, Novartis

Francis Kendall, Global Head, Statistical Programming and Analysis, Roche

Matt Smith, Director, Bristol-Myers Squibb

This panel is a read-out of a collaboration between several pharma companies with the prime objective of devising solutions to the challenges that we face as an industry. This cross-pharma consortium focused discussions on technology, standards and data with a view to creating a common framework for how we process data especially in the changing data landscape. Key focus areas included: Transition to CDSIC, Data Aggregation (including broad categories of data – Clinical Trial data, Payer databases, Registry data, Electronic Medical Records Genome data, Biomarker data and Legacy data), key technologies related to data warehousing/data reporting, validation of data analysis tools and open source approaches.

11:35 Sponsored Presentations (Opportunities Available)

12:05 pm Luncheon Presentations (Sponsorship Opportunities Available) or Lunch on Your Own

1:15 Dessert Refreshment Break in the Exhibit Hall with Poster Viewing

1:55 Chairperson’s Remarks

2:00 Interactive Medical Literature: ITN TrialShare for Open Access in Clinical Trials

Adam Asare, Ph.D., Senior Director, Bioinformatics, Immune Tolerance Network

The Immune Tolerance Network (ITN) recently achieved an unprecedented milestone in clinical trial transparency through a high profile publication in the New England Journal of Medicine that included links to the underlying clinical data and analysis code in the ITN TrialShare web portal (www.itntrialshare.org). This marks a significant advance in data sharing and transparency, allowing researchers the ability to access study data, confirm published conclusions and interactively perform their own exploratory analyses. The presentation includes lessons learned in creating interactive publications with embedded URL links and its impact on the manuscript development and review process. Metrics on system usage will also be highlighted along with scientific collaborations developed.

 

CONSORTIA EFFORTS: UPDATES, OPPORTUNITIES, DISCUSSION 

Speakers will give a 15-20 minute presentation about their consortia efforts and then convene for a panel discussion.

2:30 Open PHACTS: Practical Semantics for Drug Discovery

Lee Harland, Ph.D., CTO, Open PHACTS, Connected Discovery

The Open PHACTS project is a €20 Million collaboration between major pharma and a range of top academic institutes. Its mission it to create an open, pre-competitive, cloud-based data integration and analysis platform. This talk will describe the journey and the outcome of a major effort in applying semantic technologies to drug discovery and provide a vision for future collaboration across pharma and biotech in this area.

2:50 Enable Unified Analysis and Mining of Biological and Chemical Data from Various Sources

Daniel Stoffler, Ph.D., Senior Principal Scientist, Group Leader Cheminformatics & Statistics, F. Hoffmann-La Roche Ltd, Basel

Computational methods that rely on historical activity data such as target identification in phenotypic screens or virtual screenings based on biological profiles, compound repurposing or pathway identification have been limited due to the inaccessibility or fragmentation of the various data sources. This undertaking will capitalize on the IMI ‘OpenPHACTS’ initiative and will use novel approaches to allow scientist accessing internal and external Chemical and Biological data sources through one interface.

3:10 The European Translational Research Information and Knowledge Management Services (eTRIKS): 18 Months into a Novel IMI Project to Support Translational Research Data Management

Jay Bergeron, Director, Translational and Bioinformatics, Pfizer

eTRIKS has delivered substantial value to the translational data management community including acting as the key development partner for creating a fully open source version of the tranSMART platform (using PostgreSQL). eTRIKS has released (Nov 2013) a public server including clinical and molecular studies and is continuing to implement a tranSMART-based roadmap that includes emerging security, analytic and semantic capabilities.

3:30 tranSMART: Enabling Rapid Exploratory Analyses and Hypothesis Generation at Pfizer

Angela Gaudette, Business Analyst, Research Business Technology, Pfizer

Many organizations are seeking ways of supporting clinical endpoint and biomarker information generated by human studies and would benefit from a platform that consistently manages these data while allowing for collaborative information sharing and transfer both internally and externally. We will share our experience at Pfizer with our adoption of tranSMART, an open source platform. Learn how Pfizer has contributed to this open source initiative by enabling the search and visualization of Genome Wide Association Studies within the tranSMART platform and discover the potential of such a platform through a neuroscience case study.

3:50 PANEL DISCUSSION with Speakers

4:00 Conference Adjourns

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SOURCE

http://www.bio-itworldexpo.com/Open-Source-Solutions/